drugset
drugset / Trial / NCT03805282

Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence

NCT03805282 ↗

Phase 3 Unknown 132 enrolled Brasilia University Hospital
RandomizedParallel-groupQuadruple-blindPrevention

Summary

Introduction: Although inflating tracheal cuff using lidocaine is effective for cough suppression, it may pressure tracheal cuff too much. Intravenous continuous infusion of lidocaine has emerged recently for most general anesthesia in the context of opioid-sparing anesthesia for cancer, but the 95% effective dose (ED95) for cough suppression during anesthesia emergence is not determined yet. Objective: the objectives of this study are to determine the ED95 of continuous infusion lidocaine for suppressing cough reflex during extubation by sex and age group.

Timeline

Start
2018-03-01
Primary completion
2019-12-15
Completion
2019-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Lidocaine Other / unclassified 0.5 mg/kg Intravenous
Subject Lidocaine Other / unclassified 1 mg/kg Intravenous
Subject Lidocaine Other / unclassified 1.5 mg/kg Intravenous
Subject Lidocaine Other / unclassified 2 mg/kg Intravenous
Subject Lidocaine Other / unclassified 2.5 mg/kg Intravenous
Subject Lidocaine Other / unclassified 3 mg/kg Intravenous

Indications

No indication recorded.