Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI

Phase 4 Completed 681 enrolled Shenyang Northern Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study compared the effect of Yangxinshi on exercise tolerance of patients with percutaneous coronary intervention (PCI) for the first time with Trimetazidine.Half of participants will receive Yangxinshi and Trimetazidine mimic tablets in combination,While the other half will receive Trimetazidine and Yangxinshi mimic tablets.

Timeline

Start: 2019-08-01
Primary completion: 2020-12-31
Completion: 2020-12-31

Publications

Results Li Y, Li Y, Zhang Z, Zhang J, Chen H, Yu H, Meng X, Yuan H, Shao L, Lu Y, Liu B, Xu J, Zhang Y, Li J, Han Y; HEARTRIP investigators. Efficacy and safety of yangxinshi versus trimetazidine on exercise tolerance in patients with coronary heart disease after percutaneous coronary intervention: Multicenter, double-blind clinical trial. Phytomedicine. 2024 Dec;135:156198. doi: 10.1016/j.phymed.2024.156198. Epub 2024 Nov 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Trimetazidine	Small molecule	20 mg	—
Subject	Yangxinshi	Traditional medicine (herbal / TCM)	3 unknown	Oral

Indications

No indication recorded.