A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib on Metformin

Phase 1 Completed 18 enrolled Seagen Inc.

NaSingle-groupOpen-labelTreatment

Summary

This study is being done to look at how tucatinib might affect the way another drug (metformin) works. It will look at healthy volunteers and how tucatinib affects how the body absorbs metformin. This will help us find out whether tucatinib is safe to give together with metformin. The study will also look at how tucatinib affects how the kidneys work.

Timeline

Start: 2019-02-12
Primary completion: 2019-03-08
Completion: 2019-03-15

Publications

Zhang D, Taylor A, Zhao JJ, Endres CJ, Topletz-Erickson A. Population Pharmacokinetic Analysis of Tucatinib in Healthy Participants and Patients with Breast Cancer or Colorectal Cancer. Clin Pharmacokinet. 2024 Oct;63(10):1477-1487. doi: 10.1007/s40262-024-01412-0. Epub 2024 Oct 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metformin	Small molecule	850 mg	Oral
Subject	Tucatinib	Small molecule	150 mg	Oral
Background	Iohexol	Diagnostic / imaging agent	1500 mg	Intravenous

Indications

No indication recorded.