TNT to Increase the Clinical Complete Response Rate for Distal LARC

Summary

This is a open-label, single-arm study to investigate the safety and efficacy of total neoadjuvant treatment (TNT) in patients with locally advanced resectable rectal cancer.

Timeline

Start

2018-12-25

Primary completion

2023-12-30

Completion

2027-06-30

Publications

• Liu S, Lv G, Xu G, Wang X, Zhuang Y, Bai S, Yu H, Wu X, Ye Y, Luo H, Xu S, Wang Q, Chang H, Cai P, Pan Z, Gao Y, Chen G, Xiao W. Safety and Efficacy of a Sandwich Total Neoadjuvant Therapy Strategy for Low-Risk Distal Locally Advanced Rectal Cancer: Results From the TESS Phase II Trial. MedComm (2020). 2026 Jun 17;7(7):e70807. doi: 10.1002/mco2.70807. eCollection 2026 Jul.

Drugs

Indications