Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients

Phase 3 Completed 43 enrolled Cairo University

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of the work is to investigate the effect of using lidocaine in combination with low dose ketamine in induction of anesthesia for septic shock patients compared to normal dose of ketamine.

Timeline

Start: 2019-02-20
Primary completion: 2019-09-20
Completion: 2019-09-20

Publications

Fathy S, Hasanin A, Mostafa M, Ramzy E, Sarhan K, Almenesey T, Safina AG, Hosny O, Hamden GA, Gado AA, Mokhtar A. The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial. Anaesth Crit Care Pain Med. 2021 Feb;40(1):100731. doi: 10.1016/j.accpm.2020.06.017. Epub 2020 Sep 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ketamine	Small molecule	0.5 mg/kg	—
Comparator	Ketamine	Small molecule	1 mg/kg	—
Subject	Lidocaine	Other / unclassified	1 mg/kg	—
Background	Midazolam	Small molecule	0.05 mg/kg	—

Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients

Summary

Timeline

Publications

Drugs

Indications