Carbetocin Versus Oxytocin Plus Sublingual Misoprostol in the Management of Atonic Postpartum Hemorrhage

Completed 135 enrolled Aswan University Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin plus sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH)after vaginal delivery.

Timeline

Start: 2019-04-01
Primary completion: 2021-06-30
Completion: 2021-08-01

Publications

Parry Smith WR, Papadopoulou A, Thomas E, Tobias A, Price MJ, Meher S, Alfirevic Z, Weeks AD, Hofmeyr GJ, Gulmezoglu AM, Widmer M, Oladapo OT, Vogel JP, Althabe F, Coomarasamy A, Gallos ID. Uterotonic agents for first-line treatment of postpartum haemorrhage: a network meta-analysis. Cochrane Database Syst Rev. 2020 Nov 24;11(11):CD012754. doi: 10.1002/14651858.CD012754.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Carbetocin	Peptide	100 ug	Intravenous
Comparator	Misoprostol	Other / unclassified	400 ug	Other
Comparator	Oxytocin	Peptide	20 iu	Intravenous

Indications

No indication recorded.