Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy
Summary
Intravenous lidocaine - a potent local anesthetic with analgesic and anti-inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management in adults. In children population promising but limited evidence is available. The study was planned to evaluate the efficacy of continuous intravenous infusion of lidocaine to reduce opioid consumption during and after laparoscopic appendectomy in children.
Timeline
- Start
- 2019-03-22
- Primary completion
- 2020-01-15
- Completion
- 2020-01-17
Outcome
Missed primary endpoint
paper There was no difference in the cumulative dose of nalbuphine in the first 24 h after removal of the endotracheal tube between groups PMID 33397287 ↗
paper control group median of 0.1325 (IQR: 0.0899-0.22020) mg/kg, p = 0.63). PMID 33397287 ↗
Publications
- Kaszynski M, Stankiewicz B, Palko KJ, Darowski M, Pagowska-Klimek I. Impact of lidocaine on hemodynamic and respiratory parameters during laparoscopic appendectomy in children. Sci Rep. 2022 Aug 18;12(1):14038. doi: 10.1038/s41598-022-18243-3.
- Kaszynski M, Lewandowska D, Sawicki P, Wojcieszak P, Pagowska-Klimek I. Efficacy of intravenous lidocaine infusions for pain relief in children undergoing laparoscopic appendectomy: a randomized controlled trial. BMC Anesthesiol. 2021 Jan 5;21(1):2. doi: 10.1186/s12871-020-01218-0.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lidocaine | Other / unclassified | 1.5 mg/kg | Intravenous |