drugset / Trial / NCT03887702

Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

NCT03887702 ↗

RandomizedParallel-groupSingle-blindPrevention

Summary

This phase III trial studies the effect of hepatitis B antiviral (anti-HBV) therapy in preventing liver complications in patients with chronic or past hepatitis B virus (HBV) who are receiving anti-cancer therapy for solid tumors. People with chronic or past HBV who are undergoing therapy for cancer are at an increased risk for changes in the liver which could be minor or severe. Anti-HBV therapy acts against infections caused by HBV and may help reduce the chance that HBV gets worse or comes back in patients receiving anti-cancer therapy for solid tumors.

Timeline

Start
2020-01-17
Primary completion
2022-12-20
Completion
2022-12-20

Outcome

Outcome not reported

Stopped (Enrollment): “inability to accrue”

Drugs

EvaluationDrugModalityDoseRoute
Subject Entecavir Small molecule — Oral
Subject Tenofovir disoproxil fumarate Small molecule — Oral
Subject tenofovir alafenamide Small molecule — Oral