Impact of Intraoperative Deep Neuromuscular Blockade on NOL-guided Opioid Requirement in LSC Colorectal Surgeries

Phase 4 Unknown 100 enrolled Ciusss de L'Est de l'Île de Montréal Merck Canada Inc. · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of the present study is to answer the question whether deep neuromuscular blockade has a clinically significant impact on intra and postoperative pain, opioid requirement and anesthesia related outcomes and side effects for the early phase of recovery (24hs) after colorectal laparoscopic surgery.

Timeline

Start: 2019-05-30
Primary completion: 2022-07-01
Completion: 2022-07-01

Publications

Morisson L, Harkouk H, Othenin-Girard A, Oulehri W, Laferriere-Langlois P, Belanger ME, Idrissi M, Godin N, Verdonck O, Fortier LP, Poirier M, Henri M, Latulippe JF, Tremblay JF, Trepanier JS, Bendavid Y, Raft J, Richebe P. Impact of deep neuromuscular blockade on intraoperative NOL-guided remifentanil requirement during desflurane anesthesia in laparoscopic colorectal surgeries: A randomised controlled trial. J Clin Anesth. 2024 Dec;99:111659. doi: 10.1016/j.jclinane.2024.111659. Epub 2024 Oct 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Rocuronium	Other / unclassified	0.1 mg/kg	Intravenous

Indications

No indication recorded.