Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.

Phase 4 Completed 180 enrolled Anna Posadzy-Małaczyńska

RandomizedParallel-groupSingle-blindTreatment

Summary

The aim was to assess the effect of estrogen-progestin therapy (EPT) on serum levels of uric acid (SUA) and its precursors: xanthine (X) and hypoxanthine (HX) and on uric acid (UA) renal excretion in hypertensive postmenopausal women treated with an angiotensin-converting enzyme inhibitor (ACEI) or thiazide diuretic (HCTZ).

Timeline

Start: 2000-01-10
Primary completion: 2001-03-06
Completion: 2005-11-17

Publications

Posadzy-Malaczynska A, Rajpold K, Woznicka-Leskiewicz L, Marcinkowska J. Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women. Curr Med Res Opin. 2019 Oct;35(10):1687-1697. doi: 10.1080/03007995.2019.1612656. Epub 2019 Jun 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Estradiol	Other / unclassified	0.05 mg	Other
Subject	Hydrochlorothiazide	Unknown	25 mg	Oral
Subject	Norethindrone	Unknown	0.25 mg	Other
Subject	Perindopril	Small molecule	4 mg	Oral

Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.

Summary

Timeline

Publications

Drugs

Indications