drugset / Trial / NCT03939273
The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery
RandomizedParallel-groupQuadruple-blindTreatment
Summary
In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic inflammatory response after on-pump cardiac surgery
Timeline
- Start
- 2022-03
- Primary completion
- 2023-03
- Completion
- 2023-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ciprofloxacin | Small molecule | 500 mg | Oral |
| Comparator | Fluconazole | Small molecule | 200 mg | Oral |
| Comparator | Metronidazole | Small molecule | 500 mg | Oral |
| Comparator | Vancomycin | Other / unclassified | 500 mg | Oral |