drugset

drugset / Trial / NCT03955367

Pelvic RT Versus Prophylactic Extended-field RT in Patients With Cervical Cancer

NCT03955367 ↗

Phase 3 Unknown 638 enrolled Peking Union Medical College Hospital 940 Hospital of the People's Liberation Army Joint Logistic Support Force · collab Affiliated Cancer Hospital of Zhengzhou University · collab Beijing Obstetrics and Gynecology Hospital · collab Cancer Institute and Hospital, Chinese Academy of Medical Sciences · collab Cangzhou Central Hospital · collab China-Japan Union Hospital, Jilin University · collab First Affiliated Hospital Xi'an Jiaotong University · collab First Affiliated Hospital of Chongqing Medical University · collab First Affiliated Hospital of Guangxi Medical University · collab Fourth Affiliated Hospital of Guangxi Medical University · collab Gansu Wuwei Tumor Hospital · collab General Hospital of Benxi Iron & Steel Industry Group · collab General Hospital of Ningxia Medical University · collab Guizhou Provincial People's Hospital · collab Harbin Medical University Third Affiliated Hospital · collab Henan Provincial People's Hospital · collab Jiangsu Cancer Institute & Hospital · collab Jilin Provincial Tumor Hospital · collab Peking University First Hospital · collab Second Affiliated Hospital of Xi'an Jiaotong University · collab Second Hospital of Jilin University · collab Seventh Medical Center of PLA Army General Hospital · collab Shengjing Hospital · collab Tangshan People's Hospital · collab The Affiliated Hospital of Inner Mongolia Medical University · collab The Affiliated Tumor Hospital of Xinjiang Medical University · collab The First Affiliated Hospital of Zhengzhou University · collab The Second Affiliated Hospital of Dalian Medical University · collab Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · collab West China Second University Hospital · collab Xi'an Gaoxin Hospital · collab Xiangya Hospital of Central South University · collab Zhejiang Cancer Hospital · collab Zhongnan Hospital · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

To investigate the value of prophylactic extended-field irradiation (EFI), we conduct a randomized clinical trial to compare the efficacy and toxicity of pelvic irradiation and prophylactic EFI in selected patients with cervical cancer treated with definitive concurrent chemoradiotherapy. External beam radiation therapy is delivered with intensity-modulated radiation therapy (IMRT).

Timeline

Start: 2019-06-17
Primary completion: 2022-06-01
Completion: 2025-06-01

Publications

Background Wang W, Liu X, Meng Q, Zhang F, Hu K. Prophylactic Extended-Field Irradiation for Patients With Cervical Cancer Treated With Concurrent Chemoradiotherapy: A Propensity-Score Matching Analysis. Int J Gynecol Cancer. 2018 Oct;28(8):1584-1591. doi: 10.1097/IGC.0000000000001344.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Cisplatin	Other / unclassified	—	—
Background	Paclitaxel	Small molecule	—	—

Indications