drugset / Trial / NCT03958396
Remifentanil in Children With Obstructive Sleep Apnea
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This investigation tested the hypothesis that children with obstructive sleep apnea have an increased pharmacodynamic sensitivity to the miotic and respiratory depressant effects of the prototypic μ-opioid agonist remifentanil.
Timeline
- Start
- 2015-09-01
- Primary completion
- 2017-10-31
- Completion
- 2017-10-31
Publications
- Results Brown KA. Outcome, risk, and error and the child with obstructive sleep apnea. Paediatr Anaesth. 2011 Jul;21(7):771-80. doi: 10.1111/j.1460-9592.2011.03597.x. Epub 2011 May 3.
- Results Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, Schechter MS, Ward SD, Sheldon SH, Shiffman RN, Lehmann C, Spruyt K; American Academy of Pediatrics. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012 Sep;130(3):e714-55. doi: 10.1542/peds.2012-1672. Epub 2012 Aug 27.
- Results Bhattacharyya N, Lin HW. Changes and consistencies in the epidemiology of pediatric adenotonsillar surgery, 1996-2006. Otolaryngol Head Neck Surg. 2010 Nov;143(5):680-4. doi: 10.1016/j.otohns.2010.06.918.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Remifentanil | Small molecule | 0.05 ug/kg | — |
| Comparator | Remifentanil | Small molecule | 0.1 ug/kg | — |
| Comparator | Remifentanil | Small molecule | 0.15 ug/kg | — |
| Comparator | Remifentanil | Small molecule | 0.2 ug/kg | — |