drugset / Trial / NCT03973333

Safety and Efficacy of IMC-C103C as Monotherapy and in Combination With Atezolizumab

NCT03973333

Phase 1/2 Withdrawn Immunocore Ltd
Non-randomizedSequentialOpen-labelTreatment

Summary

IMC-C103C is an immune mobilizing monoclonal T cell receptor against cancer (ImmTAC ®) designed for the treatment of cancers positive for the tumor-associated antigen MAGE-A4. This is a first-in-human trial designed to evaluate the safety and efficacy of IMC-C103C in adult patients who have the appropriate HLA-A2 tissue marker and whose cancer is positive for MAGE-A4.

Timeline

Start
2019-05-17
Primary completion
2023-09-25
Completion
2023-09-25

Drugs

EvaluationDrugModalityDoseRoute
Subject Atezolizumab Monoclonal antibody Intravenous
Subject IMC-C103C Protein / enzyme biologic Intravenous

Indications