Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm

Phase 2 Completed 397 enrolled Swiss Tropical & Public Health Institute Public Health Laboratory Ivo de Carneri · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.

Timeline

Start: 2019-07-12
Primary completion: 2019-10-09
Completion: 2019-10-09

Outcome

Missed primary endpoint

paper Though we could not demonstrate superiority in terms of efficacy of the new formulation PMID 33150325 ↗

paper no significant difference between both formulations in terms of ERR PMID 33150325 ↗

Publications

Palmeirim MS, Bosch F, Ame SM, Ali SM, Hattendorf J, Keiser J. Efficacy, safety and acceptability of a new chewable formulation versus the solid tablet of mebendazole against hookworm infections in children: An open-label, randomized controlled trial. EClinicalMedicine. 2020 Sep 20;27:100556. doi: 10.1016/j.eclinm.2020.100556. eCollection 2020 Oct.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Mebendazole	Small molecule	—	Oral