A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery

Phase 4 Completed 100 enrolled University of Utah

RandomizedParallel-groupOpen-labelTreatment

Summary

The primary objective of this trial is to determine whether the combination of three non-opioid analgesics (multimodal analgesia) can significantly reduce or eliminate the need for opioids after ambulatory surgery. A secondary objective would be to present credible data for insurance providers about the opioid sparing effect of these medications. This data may encourage insurance providers to support payment for short term use of certain analgesics that currently require prior authorization.

Timeline

Start: 2019-08-01
Primary completion: 2023-01-31
Completion: 2023-01-31

Publications

Swenson JD, Conrad KM, Pace NL, Phillips K, Saltzman CL. Scheduled, Simultaneous Dosing of Pregabalin, Celecoxib, and Acetaminophen Markedly Reduces or Eliminates Opioid Use After ACL Reconstruction Using Allograft or Hamstring Tendon Autograft: A Randomized Clinical Trial. Orthop J Sports Med. 2022 Dec 8;10(12):23259671221140837. doi: 10.1177/23259671221140837. eCollection 2022 Dec.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Acetaminophen	Small molecule	325 mg	Oral
Subject	Celecoxib	Other / unclassified	100 mg	—
Subject	Pregabalin	Small molecule	50 mg	Oral
Background	Acetaminophen	Small molecule	325 mg	Oral
Background	Oxycodone	Other / unclassified	5 mg	Oral
Background	Oxycodone	Other / unclassified	10 mg	Oral

A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery

Summary

Timeline

Publications

Drugs

Indications