SBRT as a Vaccination for Metastatic Melanoma

Summary

Immunotherapy with PD-1 blockade is a first-line treatment for patients with advanced melanoma, but unfortunately most patients progress on this therapy. Recent evidence suggests that radiation can enhance the immune response in the presence of checkpoint blockade. The investigators aim to determine if radiation can elicit increased immune responses in patients who have stable or progressive disease on nivolumab.

Timeline

Start

2019-11-26

Primary completion

2019-11-26

Completion

2021-01-26

Outcome

Outcome not reported

Stopped (Enrollment): “Unable to enroll patients in this study”

Drugs

Indications