Efficacy of Intra-auricular Tranexamic Acid in Total Knee Arthroplasty

Phase 4 Completed 100 enrolled Centre Hospitalier de Montauban

RandomizedParallel-groupDouble-blindTreatment

Summary

Tranexamic acid an antifibrinolytic that develops its anti-haemorrhagic action by inhibiting fibrinolytic activities of plasmin and many studies confirms its effectiveness in decreasing blood loss. The aim of this study was to observe postoperative bleeding with combined intravenous and per - os administration with two intra - articular doses (1 g and 2 g) of tranexamic acid in adult patients undergoing unilateral total knee replacement.

Timeline

Start: 2019-01-01
Primary completion: 2019-12-09
Completion: 2020-01-09

Publications

Souza Neto EP, Usandizaga G. [Comparison of two doses of intra-articular tranexamic acid on postoperative bleeding in total knee arthroplasty: a randomized clinical trial]. Braz J Anesthesiol. 2020 Jul-Aug;70(4):318-324. doi: 10.1016/j.bjan.2020.03.015. Epub 2020 Jul 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Tranexamic Acid	Small molecule	10 mg/kg	Other
Comparator	Tranexamic Acid	Small molecule	1 g	Other
Comparator	Tranexamic Acid	Small molecule	2 g	Other

Indications

No indication recorded.