drugset / Trial / NCT04087746

Comparison of Aflibercept Versus Ranibizumab in Management of Diabetic Macular Edema (DME)

NCT04087746

Phase 4 Completed 400 enrolled Minia University
RandomizedParallel-groupOpen-labelTreatment

Summary

Diabetic macular edema (DME) is a sign of diabetic retinopathy that affects central vision. It is also a leading cause of visual decline in younger patients, especially in developing countries like our Arab community. Intra-vitrreal injection of anti-vascular endothelial growth factor (AVEGF) in management of DME had significant improvement in the final logMAR Un-corrected Distant Visual Acuity ( UCDVA) and logMAR Best Corrected Distant Visual Acuity (BCDVA), as well as reduction in the central retinal thickness from baseline measurement.

Timeline

Start
2017-01
Primary completion
2019-01
Completion
2019-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Aflibercept Protein / enzyme biologic 2 mg Intravitreal
Comparator Ranibizumab Monoclonal antibody 0.3 mg Intravitreal