drugset / Trial / NCT04087746
Comparison of Aflibercept Versus Ranibizumab in Management of Diabetic Macular Edema (DME)
RandomizedParallel-groupOpen-labelTreatment
Summary
Diabetic macular edema (DME) is a sign of diabetic retinopathy that affects central vision. It is also a leading cause of visual decline in younger patients, especially in developing countries like our Arab community. Intra-vitrreal injection of anti-vascular endothelial growth factor (AVEGF) in management of DME had significant improvement in the final logMAR Un-corrected Distant Visual Acuity ( UCDVA) and logMAR Best Corrected Distant Visual Acuity (BCDVA), as well as reduction in the central retinal thickness from baseline measurement.
Timeline
- Start
- 2017-01
- Primary completion
- 2019-01
- Completion
- 2019-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aflibercept | Protein / enzyme biologic | 2 mg | Intravitreal |
| Comparator | Ranibizumab | Monoclonal antibody | 0.3 mg | Intravitreal |