drugset / Trial / NCT04101877

The Sahlgrenska Anti-VEGF Study

NCT04101877

Phase 2 Active not recruiting 402 enrolled Vastra Gotaland Region
RandomizedParallel-groupQuadruple-blindTreatment

Summary

The study investigates whether patients treated for neovascular (wet) age-related macular degeneration (AMD), with intravitreal injection with bevacizumab (Avastin) after two years need more injections with retained therapy response compared to patients being treated with intravitreal injection with aflibercept (Eylea). The study also aims to evaluate if there is a difference in best-corrected visual acuity, macular thickness, recurrence interval, durability, cost efficiency, as well as vision-related quality of life.

Timeline

Start
2020-09-03
Primary completion
2026-10
Completion
2027-05

Drugs

EvaluationDrugModalityDoseRoute
Comparator Aflibercept Protein / enzyme biologic 2 mg Intravitreal
Subject Bevacizumab Monoclonal antibody 1.25 mg Intravitreal