drugset / Trial / NCT04101877
The Sahlgrenska Anti-VEGF Study
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The study investigates whether patients treated for neovascular (wet) age-related macular degeneration (AMD), with intravitreal injection with bevacizumab (Avastin) after two years need more injections with retained therapy response compared to patients being treated with intravitreal injection with aflibercept (Eylea). The study also aims to evaluate if there is a difference in best-corrected visual acuity, macular thickness, recurrence interval, durability, cost efficiency, as well as vision-related quality of life.
Timeline
- Start
- 2020-09-03
- Primary completion
- 2026-10
- Completion
- 2027-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aflibercept | Protein / enzyme biologic | 2 mg | Intravitreal |
| Subject | Bevacizumab | Monoclonal antibody | 1.25 mg | Intravitreal |