drugset / Trial / NCT04112706

Efficacy of CPP-ACP on Bleaching Related Sensitivity

NCT04112706

RandomizedCrossoverOpen-labelTreatment

Summary

Objective: The purpose of this randomized controlled split-mouth clinical trial was to evaluate the effectiveness of MI paste in reducing sensitivity associated vital bleaching. Methods: 45 subjects were randomly divided into two groups, based upon which arch received MI Paste. Group 1 bleached Maxillary arch, Group 2 bleached mandibular arch. Two weeks later subjects stopped bleaching the first arch and started second arch. Sensitivity was measured by VAS daily log scale for two weeks. Shade was taken with colorimeter and Classic Vita shade guide at baseline, immediate post-bleaching, and two weeks post-bleaching. Longitudinal sensitivity over the 14 days period of bleaching was summarized. The Wilcoxon Signed Rank test was used to compare summary measures.

Timeline

Start
2006-07-16
Primary completion
2007-02-16
Completion
2007-03-16

Drugs

EvaluationDrugModalityDoseRoute
Subject CPP-ACP Protein / enzyme biologic Topical

Indications