drugset / Trial / NCT04115462
A Relation of Morphine-induced Itch and Pain Processing
RandomizedParallel-groupDouble-blindBasic science
Summary
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1. Opioids cause itch by a spinal disinhibition mechanism (central nervous system (CNS) effect). 2. Opioids cause itch through a mast cell-destabilizing effect leading to release of histamine and tryptase in the skin where itch is evoked (peripheral mechanism).
Timeline
- Start
- 2020-01-15
- Primary completion
- 2020-05-01
- Completion
- 2020-07-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Morphine | Other / unclassified | 20 mg | — |
| Comparator | Cowhage | Unknown | — | Other |
| Comparator | Histamine | Small molecule | 1 % | Other |
Indications
No indication recorded.