Treatment of ARDS With Instilled T3

Phase 2 Active not recruiting 68 enrolled University of Minnesota

RandomizedParallel-groupOpen-labelTreatment

Summary

It is hypothesized that instillation of Liothyronine Sodium (T3) into the airspace will be safe, well tolerated, and will increase alveolar fluid clearance and decrease inflammation in patients with ARDS, reflected in improved oxygenation index (OI) and oxygenation saturation index (OSI).

Timeline

Start: 2020-03-30
Primary completion: 2026-10-31
Completion: 2026-10-31

Publications

Flory CM, Norris BJ, Larson NA, Coicou LG, Koniar BL, Mysz MA, Rich TP, Ingbar DH, Schumacher RJ. A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats-an Investigational Therapy for ARDS. J Pharmacol Exp Ther. 2021 Jan;376(1):74-83. doi: 10.1124/jpet.120.000060. Epub 2020 Oct 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Liothyronine	Small molecule	50 ug	Other

Treatment of ARDS With Instilled T3

Summary

Timeline

Publications

Drugs

Indications