drugset / Trial / NCT04123379
Neoadjuvant Nivolumab With CCR2/5-inhibitor or Anti-IL-8) for Non-small Cell Lung Cancer (NSCLC) or Hepatocellular Carcinoma (HCC)
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this research study is to study the effect of giving nivolumab with CCR2/5-inhibitor or anti-IL-8 before surgery, and after surgery, with the goal of determining if this medicine results in: 1. A significant immune response against their tumor (which the study team will see in the tumor that is taken out at the time of surgery) 2. Improvement in long term survival rates
Timeline
- Start
- 2020-03-05
- Primary completion
- 2023-08-24
- Completion
- 2025-08-24
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ADAKITUG | Monoclonal antibody | 2400 mg | Other |
| Subject | BMS-813160 | Small molecule | 300 mg | Oral |
| Subject | Nivolumab | Monoclonal antibody | 480 mg | Other |