drugset / Trial / NCT04123379

Neoadjuvant Nivolumab With CCR2/5-inhibitor or Anti-IL-8) for Non-small Cell Lung Cancer (NSCLC) or Hepatocellular Carcinoma (HCC)

NCT04123379

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this research study is to study the effect of giving nivolumab with CCR2/5-inhibitor or anti-IL-8 before surgery, and after surgery, with the goal of determining if this medicine results in: 1. A significant immune response against their tumor (which the study team will see in the tumor that is taken out at the time of surgery) 2. Improvement in long term survival rates

Timeline

Start
2020-03-05
Primary completion
2023-08-24
Completion
2025-08-24

Drugs

EvaluationDrugModalityDoseRoute
Subject ADAKITUG Monoclonal antibody 2400 mg Other
Subject BMS-813160 Small molecule 300 mg Oral
Subject Nivolumab Monoclonal antibody 480 mg Other