Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department

Summary

In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine. However, the data are sparse to support this strategy. Thus, the purpose of our research is to test non-inferiority of IV morphine alone versus IV acetaminophen and morphine in a multicenter, randomized, controlled double blind trial in ED patients with moderate to severe acute pain.

Timeline

Start

2019-12-03

Primary completion

2024-12-17

Completion

2024-12-17

Publications

• Cattin G, Viglino D, Segard J, Volteau C, Chauvin A, Galinski M, Maigre O, Delamare-Fauvel A, Le Pottier M, Debierre V, Chouihed T, Longo C, Jenvrin J, Freund Y, Montassier E. Morphine Plus Placebo vs Morphine Plus Acetaminophen for Acute Pain in the Emergency Department: A Randomized Clinical Trial. JAMA Netw Open. 2026 Feb 2;9(2):e2560250. doi: 10.1001/jamanetworkopen.2025.60250.
• Cattin G, Jenvrin J, Hardouin JB, Longo C, Montassier E. Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA). Trials. 2022 Dec 15;23(1):1016. doi: 10.1186/s13063-022-06943-0.

Drugs

Indications

No indication recorded.