drugset / Trial / NCT04150042
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells
NaSingle-groupOpen-labelTreatment
Summary
The clinical trial is a phase 1, single-arm trial that will evaluate the safety of the investigational treatment on metastatic pancreatic cancer and metastatic breast cancer. The investigational treatment will involve 2 cycles of a combination of intravenous melphalan, BCNU, vitamin B12b, and vitamin C with autologous hematopoietic stem cell infusion. A dose-escalation schedule is being employed for the vitamin C.
Timeline
- Start
- 2021-01-13
- Primary completion
- 2028-12
- Completion
- 2028-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | AQUACOBALAMIN | Unknown | — | Intravenous |
| Subject | Melphalan | Small molecule | — | Intravenous |
| Subject | Vitamin C | Other / unclassified | — | Intravenous |
| Subject | carmustine | Small molecule | — | Intravenous |