Intra-operative Uterosacral Ligament Bupivacaine Injection During Minimally Invasive Hysterectomy

Summary

This is proof of concept, phase I randomized controlled trial studying a short acting non-opioid anesthetic, bupivacaine to improve post-operative pain in gynecologic surgery patients. Patients who are undergoing minimally invasive (laparoscopic or robotic) hysterectomy will be randomized to receive no uterosacral injection, normal saline uterosacral injection, or 0.25% bupivacaine uterosacral injection just prior to colpotomy (incision around the cervix and removal of uterus) during minimally invasive hysterectomy.

Timeline

Start

2021-03-15

Primary completion

2022-10-15

Completion

2022-10-15

Publications

• Frost AS, Kohn JR, Le Neveu M, Brah T, Okonkwo O, Borahay MA, Wu H, Simpson K, Patzkowsky KE, Wang KC. Laparoscopic administration of bupivacaine at the uterosacral ligaments during benign laparoscopic and robotic hysterectomy: a randomized controlled trial. Am J Obstet Gynecol. 2023 Nov;229(5):526.e1-526.e14. doi: 10.1016/j.ajog.2023.07.047. Epub 2023 Jul 31.

Drugs

Indications