Anti-Inflammatory Drug and Endothelial Function

Phase 4 Unknown 50 enrolled Instituto de Cardiologia do Rio Grande do Sul Hospital de Clinicas de Porto Alegre · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

In this randomized double-blinded clinical trial, 400mg of hydroxychloroquine will be given daily to people over the age of 65 years with moderate-severe obstructive sleep apnea for 8 weeks. The aim of this study is to test whether hydroxychloroquine can improve endothelial function.

Timeline

Start: 2019-07-01
Primary completion: 2020-06-30
Completion: 2020-06-30

Publications

Tedesco Silva LM, Cortes A, Rossi B, Boll L, Waclawovsky G, Eibel B, Cadaval Goncalves S, Irigoyen MC, Martinez D. Effects of Hydroxychloroquine on endOthelial function in eLDerly with sleep apnea (HOLD): study protocol for a randomized clinical trial. Trials. 2021 Sep 17;22(1):638. doi: 10.1186/s13063-021-05610-0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydroxychloroquine	Small molecule	400 mg	—

Anti-Inflammatory Drug and Endothelial Function

Summary

Timeline

Publications

Drugs

Indications