drugset / Trial / NCT04176250
Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis
RandomizedSequentialSingle-blindTreatment
Summary
The purpose of this study is to assess the safety, early bactericidal activity (EBA) and pharmacokinetics of TBA-7371 in adult participants with rifampicin-sensitive tuberculosis and select dose regimen(s) for future studies.
Timeline
- Start
- 2020-01-16
- Primary completion
- 2022-10-05
- Completion
- 2022-10-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ethambutol | Small molecule | — | — |
| Comparator | Isoniazid | Small molecule | — | — |
| Comparator | Pyrazinamide | Small molecule | — | — |
| Comparator | Rifampin | Small molecule | — | — |
| Subject | TBA-7371 | Small molecule | 100 mg | Oral |
| Subject | TBA-7371 | Small molecule | 200 mg | Oral |
| Subject | TBA-7371 | Small molecule | 400 mg | Oral |