Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use

Summary

This study will use a stress (vs. placebo) exposure model, paired with single-session sham vs. active rTMS at two distinct cortical locations (dlPFC vs. mPFC in parallel groups) to assess whether rTMS neuromodulation at these alternative loci differentially influence stress-reactivity and opioid reinforcement in non-treatment seeking participants with OUD. Stress-reactivity will be measured using cognitive, affective, behavioral and biological phenotypes.

Timeline

Start

2023-04-10

Primary completion

2023-04-10

Completion

2023-04-10

Drugs

Indications