The Effect of Total Intravenous Anesthesia and Volatile Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Laparoscopic or Robotic Assisted Gastrectomy

Completed 136 enrolled Yonsei University

RandomizedParallel-groupOpen-labelPrevention

Summary

The aim of this study was to investigate the effects of total intravenous and inhalation anesthesia on the damage of endothelial glucocorticoids by comparing the concentration of syndecan-1 before and after laparoscopic or robotic assisted gastrectomy.

Timeline

Start: 2019-11-28
Primary completion: 2020-08-03
Completion: 2020-08-03

Publications

Kim NY, Kim KJ, Lee KY, Shin HJ, Cho J, Nam DJ, Kim SY. Effect of volatile and total intravenous anesthesia on syndecan-1 shedding after minimally invasive gastrectomy: a randomized trial. Sci Rep. 2021 Jan 15;11(1):1511. doi: 10.1038/s41598-021-81012-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	4 ug/ml	Intravenous
Subject	Propofol	Small molecule	4.5 ug/ml	Intravenous
Comparator	Sevoflurane	Other / unclassified	0.8 unknown	Inhaled
Comparator	Sevoflurane	Other / unclassified	1 unknown	Inhaled

Indications

No indication recorded.