drugset / Trial / NCT04192253

Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)

NCT04192253 ↗

Phase 2 Recruiting 51 enrolled The Netherlands Cancer Institute
NaSingle-groupOpen-labelTreatment

Summary

Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. Theoretically, downstaging with neoadjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive thereby diminishing the chance for morbidity.

Timeline

Start
2020-01-14
Primary completion
2024-01-01
Completion
2029-01-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Carboplatin Small molecule 5 unknown —
Subject Paclitaxel Small molecule 175 mg/m2 —