drugset / Trial / NCT04213898

SHR-1210 Combined With Albumin-bound Paclitaxel and Epirubicin Neoadjuvant for Triple Negative Breast Cancer

NCT04213898

Phase 1/2 Unknown 39 enrolled Henan Cancer Hospital
NaSingle-groupOpen-labelTreatment

Summary

Triple negative breast cancer (TNBC), characterized by estrogen receptor, progesterone receptor and HER2 negative, accounts for 10-20% of all breast cancers and usually occurs in young women. It is an aggressive and worst prognosis breast cancer subtype, which urgently requires effective treatment.The pathological complete response (pCR) of neoadjuvant therapy is associated with disease-free survival (DFS) and overall survival (OS) of breast cancer. The correlation between pathological response and long-term survival in patients with early-stage breast cancer is the strongest among patients with triple-negative breast cancer.

Timeline

Start
2020-01
Primary completion
2021-01
Completion
2023-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Camrelizumab Monoclonal antibody 200 mg Intravenous
Subject Epirubicin Small molecule 75 mg/m2 Intravenous
Subject Paclitaxel Small molecule 125 mg/m2 Intravenous