drugset / Trial / NCT04230681
Hydromorphone vs Fentanyl in Children Undergoing Tonsillectomy Surgery
Phase 0
Completed
189 enrolled
Washington University School of Medicine
National Center for Advancing Translational Sciences (NCATS) · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
A RCT to compare hydromorphone versus fentanyl for pain control following tonsillectomy or adenotonsillectomy surgery.
Timeline
- Start
- 2020-02-26
- Primary completion
- 2022-04-01
- Completion
- 2022-04-01
Publications
- Background Friedman NR, Perkins JN, McNair B, Mitchell RB. Current practice patterns for sleep-disordered breathing in children. Laryngoscope. 2013 Apr;123(4):1055-8. doi: 10.1002/lary.23709. Epub 2013 Feb 4.
- Background Brown KA. Outcome, risk, and error and the child with obstructive sleep apnea. Paediatr Anaesth. 2011 Jul;21(7):771-80. doi: 10.1111/j.1460-9592.2011.03597.x. Epub 2011 May 3.
- Background Bhattacharyya N, Lin HW. Changes and consistencies in the epidemiology of pediatric adenotonsillar surgery, 1996-2006. Otolaryngol Head Neck Surg. 2010 Nov;143(5):680-4. doi: 10.1016/j.otohns.2010.06.918.
- Miller GC, Hifko AJ, Lieu JK, Nguyen JT, Lieu JEC, Montana MC. A Triple-Blinded, Randomized, Controlled Trial Comparing Hydromorphone vs. Fentanyl for Children Undergoing Tonsillectomy. Paediatr Anaesth. 2026 Jun 18. doi: 10.1002/pan.70240. Online ahead of print.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Fentanyl | Other / unclassified | 1 ug/kg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 10 ug/kg | Intravenous |