drugset / Trial / NCT04246541

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

NCT04246541

Phase 3 Completed 48 enrolled University Hospitals Cleveland Medical Center
RandomizedParallel-groupOpen-labelTreatment

Summary

The utilization of arthroscopic surgery to treat meniscus injuries has continued to increase in recent years, partly due to a younger, more active population, and improved technology and technique. However, pain management in the post-operative period is critical to the ability to perform this procedure as an outpatient surgery. Traditionally, oral narcotic agents have been the preferred analgesic postoperatively in orthopaedic surgery. However, these agents are associated with several side effects, including nausea/vomiting, constipation, and somnolence. In addition, opioid agents have a significant potential for abuse in comparison to non-narcotic analgesics. In light of the rising opioid epidemic and nationwide initiatives to limit narcotic usage, surgeons must explore alternate pain modalities in the acute postoperative period. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties.1 Multiple prior studies have examined the beneficial effect of oral and intravenous (IV) ketorolac as an analgesic in the postoperative period,1-3 including arthroscopic meniscus surgery. However, the beneficial effects of this agent following arthroscopic meniscus surgery have not been extensively described.

Timeline

Start
2019-04-23
Primary completion
2021-09-12
Completion
2021-09-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Ketorolac Other / unclassified 10 mg Intravenous
Subject Oxycodone Other / unclassified 5 mg
Subject Oxycodone Other / unclassified 325 mg