drugset / Trial / NCT04255498
Understanding GWI: Integrative Modeling
Phase 1
Unknown
20 enrolled
South Florida Veterans Affairs Foundation for Research and Education
Nova Southeastern University · collabUnited States Department of Defense · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness. The investigator will conduct and repeat the exercise challenge before treatment and on therapy to assess the impact of the interventions on homeostatic regulation and the dynamic model identified in prior studies.
Timeline
- Start
- 2017-10-30
- Primary completion
- 2019-08-15
- Completion
- 2020-08-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Etanercept | Protein / enzyme biologic | 50 mg | — |
| Subject | Mifepristone | Small molecule | 300 mg | — |