Does Correction of 25 OH-VITAmin D With Cholecalciferol Supplementation Increase Muscle Strength in hemoDIALysis Patients?

Summary

Muscle strength decreases as renal failure progresses. Low muscle strength affects more than 50% of hemodialysis patients and leads to daily life activities impairment. In the general population, numerous studies have linked low 25OH-vitamin D (25OHD) concentrations to the loss of the muscle strength and low physical performances. Data on native vitamin D and muscle function are scarce in the chronic renal failure (CKD) population, but low 25OHD levels have been associated with poor muscle strength. In this protocol of an ongoing study named VITADIAL testing if cholecalciferol supplementation in hemodialysis patients with low 25OHD improve their muscle strength.

Timeline

Start

2018-01-08

Primary completion

2024-06-08

Completion

2024-06-08

Publications

• Bataille S, Seret G, Lavainne F, Giaime P, Serveaux M, Robert T, Bobot M, Vrigneaud L, Jean G, De Laforcade L, Prezelin-Reydit M, Chauveau P, Isnard M, Samson L, Colin A, Boury F, Viton A, Claeys-Bruno M, Pedinielli N. Cholecalciferol and muscle strength in hemodialysis patients: results from the randomized VITADIAL trial. Clin Kidney J. 2026 May 21;19(7):sfag166. doi: 10.1093/ckj/sfag166. eCollection 2026 Jul.
• Bataille S, Pedinielli N, Carreno E, Prezelin-Reydit M, Chauveau P, Jean G, Robert T, Bobot M, Seret G, Jouve E, Lavainne F, Serveaux M, Vrigneaud L, Gentile S. VITADIAL "Does correction of 25 OH-VITAmin D with cholecalciferol supplementation increase muscle strength in hemoDIALysis patients?": study protocol for a randomized controlled trial. Trials. 2021 May 25;22(1):364. doi: 10.1186/s13063-021-05302-9.

Drugs

Indications

No indication recorded.