Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

Phase 1/2 Unknown 80 enrolled Shahid Beheshti University of Medical Sciences

RandomizedParallel-groupDouble-blindTreatment

Summary

Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).

Timeline

Start: 2020-01-10
Primary completion: 2021-07-19
Completion: 2021-07-30

Publications

Daneshjou D, Zadeh Modarres S, Soleimani Mehranjani M, Shariat Zadeh SMA. Comparing the effect of sitagliptin and metformin on the oocyte and embryo quality in classic PCOS patients undergoing ICSI. Ir J Med Sci. 2021 May;190(2):685-692. doi: 10.1007/s11845-020-02320-5. Epub 2020 Jul 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metformin	Small molecule	500 mg	—
Subject	Sitagliptin	Small molecule	50 mg	—
Subject	Sitagliptin/metformin	Unknown	—	—

Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

Summary

Timeline

Publications

Drugs

Indications