drugset / Trial / NCT04276259
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
Phase 4
Completed
120 enrolled
Marta Peciña, MD PhD
National Institute of Mental Health (NIMH) · collab
RandomizedFactorialDouble-blindOther
Summary
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors \[RPE\]) to antidepressant responses (Aim1) by experimentally manipulating expected values using transcranial magnetic stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using pharmacological approaches (Aim 3).
Timeline
- Start
- 2020-10-19
- Primary completion
- 2026-01-21
- Completion
- 2026-03-31
Publications
- Snyder I, Handoko K, Neppach A, Badhan G, Karim HT, Price RB, Ferrarelli F, Dombrovski AY, Pecina M. Intermittent Theta Burst Stimulation of the Dorsomedial PFC and Expectancy-Driven Placebo Mood Effects: A Randomized Clinical Trial. JAMA Psychiatry. 2026 Jul 1;83(7):704-713. doi: 10.1001/jamapsychiatry.2026.0647.
- Pecina M, Dombrovski AY, Price R, Karim HT. Understanding the Neurocomputational Mechanisms of Antidepressant Placebo Effects. J Psychiatr Brain Sci. 2021;6:e210001. doi: 10.20900/jpbs.20210001. Epub 2021 Feb 15.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Buprenorphine | Other / unclassified | 0.3 mg | Intramuscular |
| Subject | Naltrexone | Small molecule | 50 mg | Oral |