a Single HYAJOINT Plus Combined With a Single PPR Versus a Single PRP for Knee OA

Phase 2 Completed 85 enrolled Kaohsiung Veterans General Hospital.

RandomizedParallel-groupSingle-blindTreatment

Summary

Intraarticular hyaluronan or platelet-rich plasma (PRP) is each effective in the treatment for knee osteoarthritis (OA). The efficacy of combined hyaluronan with PRP for knee OA remained unclear. This study aimed to investigate the efficacy of a single intraarticular hyaluronan (HYAJOINT Plus) combined with a single PRP versus a single intraarticular PRP in patients with knee OA.

Timeline

Start: 2018-08-01
Primary completion: 2019-01-10
Completion: 2019-07-10

Outcome

Met primary endpoint

paper However, at 6-month follow-up, the combined-injection group achieved significantly better VAS pain reduction (p = 0.020). PMID 33420185 ↗

Publications

Sun SF, Lin GC, Hsu CW, Lin HS, Liou IS, Wu SY. Comparing efficacy of intraarticular single crosslinked Hyaluronan (HYAJOINT Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis. Sci Rep. 2021 Jan 8;11(1):140. doi: 10.1038/s41598-020-80333-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hyaluronan	Other / unclassified	3 ml	Other
Subject	Platelet Rich Plasma	Other / unclassified	3 ml	Other