The Effect of Curcumin on the Development of Prednisolone-induced Hepatic Insulin Resistance

Summary

The aim of this study is to investigate whether ingestion of curcumin will prevent hepatic insulin resistance (assessed by homeostatic model assessment of insulin resistance (HOMA-IR)) induced by short-term oral glucocorticoid (prednisolone) administration in overweight and obese participants. As a secondary endpoint it will be investigated if prednisolone administration induce or worsen the degree of NAFLD in overweight or obese participants using magnetic resonance (MR) spectroscopy (MRS), and if curcumin can ameliorate this effect. Also, the possible anti-inflammatory effect of curcumin will be elucidated as a range of inflammatory markers before and after intervention will be measured. Thus, prednisolone treatment is used as a model of development of pre-diabetes.

Timeline

Start

2019-12-01

Primary completion

2021-06-07

Completion

2021-06-11

Publications

• Amiri D, Hellmann PH, Thyssen JP, Skov L, Kolko M, Gether L. Intraocular Pressure During Short-Term Topical or Systemic Corticosteroid Treatment: Analysis of 3 Randomized Clinical Trials. JAMA Dermatol. 2026 May 13:e261183. doi: 10.1001/jamadermatol.2026.1183. Online ahead of print.

Drugs

Indications