drugset / Trial / NCT04329650

Efficacy and Safety of Siltuximab vs. Corticosteroids in Hospitalized Patients With COVID-19 Pneumonia

NCT04329650

Phase 2 Completed 163 enrolled Judit Pich Martínez
RandomizedParallel-groupOpen-labelTreatment

Summary

In our center up to 25% of the hospitalized patients with COVID-19 progress and need an intensive care unit. It is urgent to find measures that can avoid this progression to severe stages of the disease. We hypothesize that the use of anti-inflammatory drugs used at the time they start hyperinflammation episodes could improve symptoms and prognosis of patients and prevent their progression sufficiently to avoid their need for be admitted to an Intensive Care Unit.

Timeline

Start
2020-04-15
Primary completion
2021-02-26
Completion
2021-02-26

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexamethasone Small molecule 6 mg Oral
Subject Siltuximab Monoclonal antibody 11 mg/kg Intravenous

Indications