drugset / Trial / NCT04329806
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity
Phase 1
Terminated
10 enrolled
Italo Biaggioni
National Heart, Lung, and Blood Institute (NHLBI) · collab
RandomizedParallel-groupTriple-blindBasic science
Summary
The purpose of this study is to study the role of sympathetic mechanisms involved in chronic regulation of cardiovascular and metabolic abnormalities seen in obesity. The investigators will study the effects chronic sympathetic inhibition on insulin sensitivity, inflammation and endothelial function in obese hypertensive human subjects.
Timeline
- Start
- 2021-02-23
- Primary completion
- 2022-07-27
- Completion
- 2022-07-27
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 5 mg | — |
| Subject | Moxonidine | Small molecule | 0.2 mg | — |