Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin

Phase 1 Completed 487 enrolled University Hospital, Bonn

RandomizedFactorialDouble-blindBasic science

Summary

The study aims to examine a behavioral and neural framework for understanding the sex-specific effects of the neuropeptide oxytocin (OXT). Using hormonal, behavioral and neuroimaging readouts, it is planned to explore the interplay of OXT and estradiol as a potential mechanism mediating sexual dimorphic effects.

Timeline

Start: 2016-09-18
Primary completion: 2020-01-25
Completion: 2020-01-25

Publications

Background Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR. The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage. 2002 Sep;17(1):317-23. doi: 10.1006/nimg.2002.1179.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Estradiol	Other / unclassified	2 mg	Topical
Subject	Oxytocin	Peptide	24 iu	Intranasal

Indications

No indication recorded.