Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation

Phase 3 Active not recruiting 250 enrolled University Hospital, Brest

RandomizedParallel-groupDouble-blindTreatment

Summary

The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if intubated in pre -hospital) by Isoflurane using an ANACONDA ™ type system, compared to a conventional intravenous sedation strategy.

Timeline

Start: 2020-08-06
Primary completion: 2025-09-14
Completion: 2026-09-02

Publications

Bailly P, Egreteau PY, Ehrmann S, Thille AW, Guitton C, Grillet G, Reizine F, Huet O, Jaber S, Nowak E, L'her E. Inased (inhaled sedation in ICU) trial protocol: a multicentre randomised open-label trial. BMJ Open. 2021 Feb 19;11(2):e042284. doi: 10.1136/bmjopen-2020-042284.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Isoflurane	Other / unclassified	—	Inhaled
Comparator	Propofol	Small molecule	—	Intravenous

Indications

No indication recorded.