Convalescent Plasma for COVID-19

Summary

The purpose of this proof of concept study is to provide COVID-19 convalescent plasma to patients with moderate to severe COVID-19 and assess: * the titer of anti-COVID-19 antibodies in the donors and in the patients before and after treatment; * the in-depth analysis of immunological parameters in the donors and in recipient before and after treatment; * the impact of plasma transfusion on the reduction of viral load and inflammation * safety and tolerability * clinical efficacy

Timeline

Start

2020-07-20

Primary completion

2020-12-20

Completion

2021-06-30

Publications

• Background Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, Wang F, Li D, Yang M, Xing L, Wei J, Xiao H, Yang Y, Qu J, Qing L, Chen L, Xu Z, Peng L, Li Y, Zheng H, Chen F, Huang K, Jiang Y, Liu D, Zhang Z, Liu Y, Liu L. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA. 2020 Apr 28;323(16):1582-1589. doi: 10.1001/jama.2020.4783.

Drugs

Indications