Drugs / Fresh Frozen Plasma
Fresh Frozen Plasma
Trials 20
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 12 trials | ||||||
| Phase 1 | NCT02460731 | May 2015 → Dec 2017 | progressive supranuclear palsy | University of California, San Francisco | Completed | No outcome recorded |
| Phase 1 | NCT00968487 | Jun 2010 → Dec 2011 | — | HemCon Medical Technologies, Inc | Completed | No outcome recorded |
| Phase 24 trials | ||||||
| Phase 2 | NCT07160426 | Jul 2026 → Jun 2028 expected | infectious disease with sepsis | Beth Israel Deaconess Medical Center | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT01716208 | Jan 2013 → Oct 2019 | B-cell chronic lymphocytic leukemia | Joseph Tuscano | Completed | No outcome recorded |
| Phase 2 | NCT00892827 | Apr → Jul 2009 | B-cell chronic lymphocytic leukemia | Wolfson Medical Center | Unknown | No outcome recorded |
| Phase 2 | NCT00222625 | Sep 2005 → Sep 2006 | intracerebral hemorrhage | University Of Perugia | Unknown | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT06062888 | Feb 2026 → Aug 2028 expected | traumatic brain injury | Northwestern University | Recruiting | No outcome recorded |
| Phase 33 trials | ||||||
| Phase 3 | NCT02637427 | Feb 2016 → Jun 2019 | blood coagulation disease, hemorrhagic disease | Rutgers, The State University of New Jersey | Completed | No outcome recorded |
| Phase 3 | NCT01670812 | Jan 2012 → Jun 2013 | chronic lymphocytic leukemia/small lymphocytic lymphoma | The First Affiliated Hospital with Nanjing Medical University | Unknown | No outcome recorded |
| Phase 3 | NCT00953901 | Jul 2006 → Dec 2007 | blood coagulation disease | Mayo Clinic | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT03202524 | Dec 2017 → Jul 2018 | cirrhosis of liver | Montefiore Medical Center | Withdrawn | No outcome recorded |
| Phase 4 | NCT02366845 | Jun 2012 → Jun 2015 | liver disorder | University of Colorado, Denver | Completed | No outcome recorded |
| Phase 4 | NCT00928915 | Jul 2009 → Jan 2015 | intracerebral hemorrhage | Heidelberg University | Completed | No outcome recorded |
| Phase not applicable7 trials · 1 missed | ||||||
| — | NCT07685093 | Jul → Oct 2026 expected | idiopathic nephrotic syndrome | Qamar Shafiq | Not yet recruiting | No outcome recorded |
| — | NCT06642493 | May → Dec 2024 overdue | dengue shock syndrome | Sheikh Hasina National Institute of Burn and Plastic Surgery | Active not recruiting | No outcome recorded |
| — | NCT04107883 | Oct 2023 → Dec 2024 | chronic liver failure | Beijing Chao Yang Hospital | Unknown | No outcome recorded |
| — | NCT04683614 | Oct 2020 → May 2022 | — | National Cancer Institute, Egypt | Completed | No outcome recorded |
| — | NCT04365439 | Jul → Dec 2020 | COVID-19 | Enos Bernasconi | Unknown | No outcome recorded |
| — | NCT02689232 | Feb 2016 → Mar 2018 | — | Institute of Liver and Biliary Sciences, India | Completed | No outcome recorded |
| — | NCT01903863 | Jul 2013 → Feb 2016 | — | Duke University | Completed | Missed primary |
| Comparator or background therapy24 trials | ||||||
| Phase 1 | NCT02930226 Comparator | Feb 2017 → Aug 2018 | — | U.S. Army Medical Research and Development Command | Completed | No outcome recorded |
| Phase 1 | NCT00770718 Comparator | Apr 2008 → Apr 2010 | intracerebral hemorrhage | University of Utah | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT04794348 Comparator | May 2021 → Mar 2022 | — | Teleflex | Withdrawn | No outcome recorded |
| Phase 2 | NCT04374539 Background | Apr 2020 → Jun 2021 | COVID-19 | Fundacion Clinic per a la Recerca Biomédica | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT04434001 Comparator | Feb 2020 → May 2021 | acquired coagulation factor deficiency, acute lung injury, congenital heart disease, hemorrhagic disease | IRCCS Policlinico S. Donato | Terminated | No outcome recorded Stop: Enrollment |
| Phase 2 | NCT03715348 Comparator | Mar 2019 → Jan 2020 | hemorrhagic disease | Queen Mary University of London | Completed | No outcome recorded |
| Phase 3 | NCT07094087 Comparator | Sep 2025 → Nov 2026 expected | — | CSL Behring | Recruiting | No outcome recorded |
| Phase 3 | NCT03444324 Comparator | Apr 2018 → Sep 2023 | coagulation protein disease | Biotest | Completed | Met primary |
| Phase 3 | NCT02750150 Comparator | Jul 2013 → Apr 2016 | blood coagulation disease | University Hospital, Lille | Completed | No outcome recorded |
| Phase 3 | NCT01545635 Comparator | Mar 2012 → Feb 2016 | brain injury | Medical University Innsbruck | Terminated | No outcome recorded |
| Phase 3 | NCT00803101 Comparator | Feb 2009 → Nov 2012 | — | CSL Behring | Completed | Met primary |
| Phase 3 | NCT00708435 Comparator | Jun 2008 → Nov 2010 | blood coagulation disease | CSL Behring | Completed | Met primary |
| Phase 3 | NCT00618098 Comparator | May 2008 → Mar 2012 | — | Octapharma | Completed | No outcome recorded |
| Phase 4 | NCT06144125 Comparator | Mar → Sep 2026 overdue | heart valve disorder | Konkuk University Medical Center | Recruiting | No outcome recorded |
| Phase 4 | NCT06144112 Comparator | Sep 2025 → Mar 2026 overdue | liver disorder | Konkuk University Medical Center | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06144099 Comparator | Mar 2024 → Apr 2025 | osteoarthritis, hip, prostate cancer | Konkuk University Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT04244981 Comparator | Oct 2023 → Mar 2025 | cardiac valvular defect | SHI Jia | Terminated | No outcome recorded |
| Phase 4 | NCT02777424 Comparator | Jan 2016 → Mar 2019 | intracerebral hemorrhage | Fondation Ophtalmologique Adolphe de Rothschild | Completed | No outcome recorded |
| Phase 4 | NCT02738190 Comparator | Jan 2015 → May 2016 | hemorrhagic disease | IRCCS Policlinico S. Donato | Completed | No outcome recorded |
| Phase 4 | NCT02253082 Comparator | Nov 2014 → Sep 2016 | thoracic aortic aneurysm | Rigshospitalet, Denmark | Completed | No outcome recorded |
| Phase 4 | NCT01221389 Comparator | Mar → Dec 2012 | abdominal aortic aneurysm, blood coagulation disease | Ottawa Hospital Research Institute | Withdrawn | No outcome recorded Stop: Business |
| Phase 4 | NCT00994045 Comparator | Jun 2010 → Aug 2013 | — | University of Edinburgh | Completed | No outcome recorded |
| — | NCT02726620 Background | Jan → Dec 2017 | hypotensive disorder | Vanderbilt University Medical Center | Completed | No outcome recorded |
| — | NCT02429453 Comparator | Apr 2015 → Mar 2016 | brain injury, intracerebral hemorrhage | University of Utah | Withdrawn | No outcome recorded |
News releases announcing trial results or a regulatory action · 3
| Date | Issuer | Release |
|---|---|---|
| 2023-02-02 | Octapharma | Regulatory European authorities approve lyophilised S/D treated plasma octaplasLG® for pre-hospital transfusion octapharma.com ↗
Octapharma AG today announced that European medical authorities have approved the lyophilised presentation of the well-established octaplasLG® - pharmaceutically-licensed S/D treated plasma for transfusion. |
| 2021-04-07 | Octapharma | Results Study suggests that 4F-PCC can be used as a substitute for frozen plasma for the treatment of bleeding during cardiac surgery octapharma.com ↗
Octapharma announced today the results from a study, investigating whether four-factor prothrombin complex concentrate (4F-PCC) can be used as a substitute for frozen plasma (FP) for the treatment of bleeding during cardiac surgery. |
| 2021-03-03 | ADMA Biologics, Inc. | Regulatory ADMA Biologics Expands Global Regulatory Approval Presence and Announces FDA Approval to Commence Hepatitis B Plasma Collections admabiologics.com ↗
In conjunction with the South Korean approval, ADMA additionally announced the Kennesaw plasma collection center received FDA approval to implement a Hepatitis B immunization program, enabling ADMA to collect source plasma from donors immunized with an FDA-licensed Hepatitis B vaccine. |
All press releases naming this drug 5 releases
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 46 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | fresh frozen plasma | “two RCTs of prothrombin complex concentrates (PCC) versus fresh frozen plasma (FFP) (47 participants)” PMID 37870112 ↗ Oct 202342“Plasma exchanges with 5% human albumin and fresh frozen plasma” NCT04374539 ↗ “regimen including Fresh frozen plasma 400ml IV day0” NCT01670812 ↗ “Fresh Frozen Plasma (FFP)/Cryoprecipitate (Cryo)” NCT03444324 ↗ “BE1116 compared with fresh frozen plasma (FFP)” NCT07094087 ↗ “Fresh Frozen Plasma (FFP)” NCT02750150 ↗ “Fresh Frozen Plasma” NCT00968487 ↗ |
| Known as | Blood plasma | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04365439 ↗ |
| Known as | FFP | “Fresh Frozen Plasma (FFP) is a viable, cost-effective alternative to intravenous albumin for managing diuretic resistant edema in children with idiopathic nephrotic syndrome...” NCT07685093 ↗12“Patients in the intervention group will receive fresh frozen plasma (FFP) transfusion at a dose of 10-15 mL/kg body weight.” NCT06642493 ↗ “according to the Thromboelastography (TEG) test, CK r-time prolongation, fresh frozen plasma transfusion (FFP) is performed” NCT06144099 ↗ “Patients randomised to the comparator arm will receive Fresh Frozen Plasma (FFP)” NCT03715348 ↗ “Fresh Frozen Plasma (FFP) in Patients Under Vitamin K Antagonist Therapy” NCT00618098 ↗ “Rituximab (Mabthera) , FFP (Fresh Frozen Plasma)” NCT00892827 ↗ “Fresh Frozen Plasma (FFP)” NCT04794348 ↗ “Fresh Frozen Plasma (FFP)” NCT03202524 ↗ “Fresh frozen plasma (FFP)” NCT00928915 ↗ “Fresh Frozen Plasma (FFP)” NCT02750150 ↗ “Fresh Frozen Plasma (FFP)” NCT06062888 ↗ |
| Known as | Human Plasma | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01221389 ↗ |
| Action | Restore | “Plasma is commonly used for vitamin K antagonist (VKA) reversal” PMID 26135740 ↗ Jul 2015 |
| Modality | Protein / enzyme biologic | “fresh frozen plasma (FFP)” PMID 37870112 ↗ Oct 2023 |
| Route | Intravenous | “fresh frozen plasma infusions intravenously” NCT00618098 ↗ |