drugset

drugset / Trial / NCT04374799

Heparin vs Placebo for Cardiac Catheterization

NCT04374799 ↗

Phase 3 Recruiting 1623 enrolled London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

RandomizedParallel-groupTriple-blindPrevention

Summary

Patients undergoing cardiac catheterization will be randomized to 3 groups: no anticoagulant, low dose anticoagulant and high dose anticoagulant.

Timeline

Start: 2020-10-05
Primary completion: 2026-08
Completion: 2026-12

Publications

Lavi S, Shadpour S, Allen E, Ogunsakin RE, Mehta SR. Design and rational of the the PRACTICAL-HERO trial: A randomized trial of higher and lower doses of heparin vs placebo for elective diagnostic coronary angiography. Am Heart J. 2026 Aug;298:107441. doi: 10.1016/j.ahj.2026.107441. Epub 2026 Apr 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Heparin	Other / unclassified	25 iu/kg	—
Comparator	Heparin	Other / unclassified	50 iu/kg	—

Indications