drugset / Trial / NCT04396587

Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone

NCT04396587

Phase 4 Completed 80 enrolled Peking University People's Hospital
RandomizedParallel-groupTriple-blindTreatment

Summary

This study aimed to investigate Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone in female patients. Methods: A total of 60 patients were randomly divided into 4 groups, with 20 patients in each group. Sufentanil(0.1μg/kg), Hydromorphone(20μg/kg), or Oxycodone(60μg/kg) ,saline(10ml)was administered before anesthesia induction. Bispectral Index (BIS), Respiratory rate(RR), other non-analgesic effects at Tb (entering room), T0 (drug administration), T1 (2min), T2 (4min), T3(6min), T4(8min), T5(10min), T6(20min) were recorded.

Timeline

Start
2020-05-20
Primary completion
2023-01-01
Completion
2023-06-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Hydromorphone Other / unclassified 20 ug/kg
Subject Oxycodone Other / unclassified 60 ug/kg
Subject Sufentanil Other / unclassified 0.1 ug/kg