drugset
drugset / Trial / NCT04399148

Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.

NCT04399148 ↗

Completed 13 enrolled Universitaire Ziekenhuizen KU Leuven
RandomizedCrossoverDouble-blindBasic science

Summary

In order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the administration of certain antipruritics. Besides, the influence of these antipruritics on the dermal blood flow response induced by the topical application of cinnamaldehyde and capsaicin will be evaluated. Changes in dermal blood flow will be measured with laser speckle contrast imaging.

Timeline

Start
2019-06-11
Primary completion
2019-09-23
Completion
2019-09-23

Drugs

EvaluationDrugModalityDoseRoute
Subject Aprepitant Other / unclassified 125 mg Oral
Subject Desloratadine Small molecule 5 mg Oral
Subject Ketotifen Small molecule 1 mg Oral

Indications

No indication recorded.